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MCQs in Tropical Medicine

Rob Skelly DTM+H FRCP

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Answer 51

Hepatocellular carcinoma
True a. is more common in men than women
False b. is radiosensitive
True c. is associated with intake of aflotoxin
True d. usually presents with weight loss, right hypochondrial pain and hepatomegaly

False e. progress of the disease can be monitored by serial measurement of the tumour marker inhibin

a. In Africa the ratio of male to female cases is 4:1 and most cases occur in the 20-40 years age group. It tends to occur at a later age in Asia and Europe.

b. Adriamicin causes tumour regression in 20-30% of cases. Arterial embolization and hepatic resection have some success in selected patients.

c. Hepatitis B, hepatitis C, and aflotoxin are each associated with the development of hepatocellular carcinoma.

d. Presentation with hepatomegaly, abdominal pain and weight loss is typical in endemic areas. In low incidence areas hepatocellular carcinoma usually presents in known cirrhotics.

e. Alpha-fetoprotein is the tumour marker.

Copyright: Rob Skelly 2006