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MCQs in Tropical Medicine

Rob Skelly DTM+H FRCP

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Answer 37

The following drugs are contraindicated or should be used with caution in epileptics:

False a. doxycycline
True b. chloroquine
True c. ciprofloxacin
True d. mefloquine

False e. metronidazole

Mefloquine is contra-indicated in epileptics. In the normal population there is a 1 in 10,000 chance of serious neuropsychiatric complications. The risk is greater in epileptics.

Chloroquine should only be used with caution as it reduces seizure threshold. Doxycycline is an acceptable alternative for malaria prophylaxis. It is suitable for short term use and has the additional advantage of protecting against rickettsial infections, plague and leptospirosis.

Ciprofloxacin and other quinolones should be used with caution in epilepsy as they lower seizure threshold and may induce convulsions

Copyright: Rob Skelly 2006