Answer 32
Quinine
False a. is gametocidal for mature gametocytes of Plasmodium falciparum.
True b. is active against schizonts of Plasmodium malariae
True c. resistance occurs in Plasmodium falciparum in South East Asia
True d. cerebrospinal fluid levels are much lower than serum levels following oral or intravenous administration
True e. causes hypoglycaemia
Quinine is schizonticidal to all four types of malaria. The gametocytes of P.vivax, P.ovale and P.malariae are also susceptible. The mature gametocytes of P.falciparum and the hypnozoites of P.ovale and P.vivax are not susceptible.
Quinine-resistant P.falciparum has been reported in South East Asia.
Cerebrospinal fluid levels are 2-5% of the serum level.
